Drop all connections by using Following Query
USE master
GO
ALTER DATABASE DBName
SET OFFLINE WITH ROLLBACK IMMEDIATE
ALTER DATABASE DBName
SET ONLINE
You can kill all the processes using a database with this code:
USE master
go
DECLARE @dbname sysname
SET @dbname = 'Database'
DECLARE @spid int
SELECT @spid = min(spid) from master.dbo.sysprocesses where dbid = db_id(@dbname)
WHILE @spid IS NOT NULL
BEGIN
EXECUTE ('KILL ' + @spid)
SELECT @spid = min(spid) from master.dbo.sysprocesses where dbid = db_id(@dbname) AND spid > @spid
END
Remember you cannot kill System connections with second command.